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Napabucasin (CAS 83280-65-3)

Napabucasin, also known by its chemical name BBI608, is a pharmacological compound that has generated interest in the field of oncology due to its potential in cancer treatment. Its Chemical Abstracts Service (CAS) registry number is 83280-65-3.

Products Description

Napabucasin

Napabucasin CAS 83280 65 3

Product Name: Napabucasin
CAS No.: 83280-65-3
Molecular formula: C14H8O4
Molecular weight: 240.21
Purity: ≥99%
Description: Napabucasin is a cancer cell stemness inhibitor which attenuates the progression of prostate cancer.

Product Description

Napabucasin, also known by its chemical name BBI608, is a pharmacological compound that has generated interest in the field of oncology due to its potential in cancer treatment. Its Chemical Abstracts Service (CAS) registry number is 83280-65-3. Here’s a description of Napabucasin:

Chemical Structure: Napabucasin is a small organic compound with a relatively complex chemical structure. It is a member of a class of drugs known as STAT3 (signal transducer and activator of transcription 3) inhibitors. The structure includes multiple carbon and oxygen atoms arranged in a unique pattern. The complex structure is designed to target specific cellular pathways associated with cancer.

Pharmacological Significance: Napabucasin is primarily investigated for its potential in cancer therapy, particularly in the treatment of solid tumors, such as colorectal, pancreatic, and gastric cancers. It works by targeting and inhibiting the activity of STAT3, a protein that plays a crucial role in cancer progression, tumor growth, and immune evasion.

Mechanism of Action: Napabucasin’s mechanism of action involves suppressing the activation of STAT3, which is known to promote cancer cell survival, proliferation, and resistance to therapy. By inhibiting STAT3, Napabucasin may help reduce the growth and spread of cancer cells and sensitize them to other cancer treatments like chemotherapy and radiation therapy.

Clinical Trials: Napabucasin has been the subject of several clinical trials to assess its safety and efficacy in cancer treatment. Results from these trials have been mixed, with some studies showing promise in inhibiting tumor growth and others suggesting more research is needed to fully understand its potential.

Potential for Combination Therapy: One of the notable aspects of Napabucasin is its potential for use in combination therapy. It may enhance the effectiveness of other cancer treatments when used in conjunction with them, which makes it a candidate for further investigation in the field of oncology.

Dosage and Safety: Dosage and administration of Napabucasin, if approved for clinical use, would be determined by healthcare professionals based on the specific cancer being treated and the patient’s individual health circumstances. As with any medication, the safety and potential side effects of Napabucasin would be closely monitored during its use.

In summary, Napabucasin is a pharmaceutical compound with a complex chemical structure that is primarily being studied for its potential role in cancer therapy. It is designed to inhibit the activity of STAT3, a protein linked to cancer cell proliferation and resistance. While promising in some studies, further research is necessary to establish its efficacy and safety in cancer treatment. It may have future applications in combination therapies for solid tumors.

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