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Hexamethylphosphoramide (680-31-9): Properties, Applications, and Safety Considerations

what is Hexamethylphosphoramide (680-31-9)

Hexamethylphosphoramide (HMPA), with the chemical formula (CH3)3P=O, is an organophosphorus compound widely used in various industrial applications. This blog will delve into the properties, applications, and safety considerations of HMPA, shedding light on its significance in different fields.

Properties of Hexamethylphosphoramide:

Hexamethylphosphoramide is a colorless liquid with a distinctive odor. It has a molecular weight of 179.22 g/mol and a boiling point of approximately 233°C. HMPA is highly soluble in polar solvents such as water, ethanol, and acetone. Its high boiling point and excellent solubility make it a versatile compound for numerous applications.

Hexamethylphosphoramide (680-31-9)
hpma supplier

Applications of Hexamethylphosphoramide:

  1. Solvent and Reaction Medium: HMPA finds extensive use as a solvent and reaction medium in organic synthesis. It exhibits remarkable solvating properties, aiding in the dissolution of various compounds that are otherwise insoluble in conventional solvents. Its ability to enhance reactivity and facilitate reactions makes it valuable in pharmaceutical, agrochemical, and polymer industries.
  2. Catalyst and Ligand: HMPA acts as a catalyst or ligand in certain chemical reactions. It can increase reaction rates and improve selectivity in diverse catalytic processes, including metal-catalyzed reactions. The unique coordination abilities of HMPA make it an effective ligand in transition metal complexes.
  3. Polymer Processing: In polymer science, HMPA serves as a processing aid, particularly in the production of polyacrylonitrile fibers. It enhances the spinnability of the polymer, resulting in improved fiber quality and mechanical properties.

Safety Considerations:

While Hexamethylphosphoramide offers valuable applications, it is essential to handle it with care due to its potential hazards. Here are some important safety considerations:

  1. Toxicity: HMPA is classified as a toxic compound and can be harmful if inhaled, swallowed, or absorbed through the skin. Prolonged or repeated exposure may cause adverse health effects. Adequate ventilation, personal protective equipment, and proper handling practices should be employed when working with HMPA.
  2. Environmental Impact: Hexamethylphosphoramide can have detrimental effects on aquatic organisms and the environment. It is crucial to prevent its release into waterways or soil during handling, storage, and disposal. Following appropriate waste management protocols is necessary to minimize environmental impact.
  3. Regulatory Compliance: Ensure compliance with local regulations and guidelines when using Hexamethylphosphoramide. Familiarize yourself with any restrictions, permits, or reporting requirements associated with its use.


Hexamethylphosphoramide (680-31-9) is a versatile compound with diverse applications in various industries. Its solvating properties, catalytic capabilities, and role as a polymer processing aid make it invaluable in organic synthesis, chemical reactions, and polymer science. However, it is crucial to prioritize safety precautions when handling HMPA due to its toxicity and potential environmental impact. Adhering to proper safety practices and regulatory guidelines will enable the responsible and effective use of Hexamethylphosphoramide in industrial settings.

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