The future CBD(Cannabidiol) industry will develop
The economic value of CBD is enormous, and the prospect of synthesizing CBD is broad.
According to New Frontier Data, CBD is a rapidly growing subcategory of the cannabis industry, with sales triple from 2014 to 2017, reaching $367 million, and is expected to reach $1.3 billion by 2022.
Since the US Congress passed the Agriculture Act last year, sales have accelerated, but the Agriculture Act has ostensibly removed marijuana from the federal ban, while retaining the FDA’s right to regulate CBD, ultimately placing it in a legal gray area.
Nevertheless, various products such as foods, gums, skincare products, and CBD oils containing CBD ingredients have erupted in the US market. Now, large listed retailers like CVS and Walgreens are planning to sell CBD products.
In the medical field, the best way to profit from CBD is to obtain patents, while the only way to obtain patents in the public domain is to combine CBD with newly discovered patented compounds that have been proven to have medical benefits.
Whoever can first use synthetic CBD for the development of derivatives will seize the market opportunity!
CAS: 504-15-4 3187-58-4 2524-37-0 4299-72-3102342-60-9 500-49-2 55382-52-0 21855-51-6 46113-76-2 102342-62-1500-66-3 58016-28-7 38862-65-65465-20-3 102342-63-2500-67-4 6121-77-3 38862-66-7 46733-28-2 102342-64-3, achieving tonnage levels from one carbon atom to 10 carbon atoms.
From products to their derivatives, our cost and quality are among the best in China.
What can we provide
Our company shandong voyage has been committed to developing CBD intermediate products. CAS: 504-15-4 3187-58-4 2524-37-0 4299-72-3102342-60-9 500-49-2 55382-52-0 21855-51-6 46113-76-2 102342-62-1500-66-3 58016-28-7 38862-65-65465-20-3 102342-63-2500-67-4 6121-77-3 38862-66-7 46733-28-2 102342-64-3, achieving tonnage levels from one carbon atom to 10 carbon atoms.
CAS: 22972-51-6 reacts with 5-Heptylresorcinol, and we provide 2 tons of both materials per month. We can provide p-Toluenesulfonic acid monohydrate palladium carbon (10%, 3%) as the catalyst in the reaction.
2. Chemical synthesis method
At present, cannabis bisphenol products mainly come from chemical synthesis methods, mainly with international patents. The comparison of different methods is as follows:
1) Patent WO2006053766A1 (a purification method for cis tetrahydrocannabinol and trans tetrahydrocannabinol) catalyzes the synthesis of the target product using zinc chloride. The column crystallization purification process was used, with a purity of only 97.1% and a yield of only 22%. Because the maximum impurity in the reaction process is dimer, reaching over 20%, and this impurity requires more than 3 crystallization attempts to reduce to within 0.1% (meeting the requirements of the raw material drug index). When qualified raw materials are finally obtained, the total yield is only 13%, and the process cost is relatively high.
2) Patent US20090036523A1 (a precursor drug of cannabinoid and a method for using its components) uses olive alcohol as the starting material, catalyzed by p-toluenesulfonic acid, to obtain the target product in a one-step process. However, the reaction system is complex, with many isomers and dimers, and the post-processing is troublesome. Column chromatography purification is required with a low yield of only 24%.
3) Patent US20100298579A1 (a method for preparing cannabinoid) uses methyl 2,4-dihydroxy-6-pentanylbenzoate as the starting material, and is catalyzed by boron trifluoride ether to prepare a coupling methyl ester intermediate (1).
The reaction purity is slightly higher than that of the one-step method, and the isomers and dimers are also significantly less than that of the one-step method. However, after acid and alkali treatment, the purity of the methyl ester intermediate after coupling is still only about 75%, and the melting point of the compound may be low, making it unable to crystallize. Methyl ester intermediate (1) cannot be recrystallized and purified through conventional methods, thus failing to meet the chemical purity and impurity index requirements as a key intermediate for raw materials.